药学翻译-硫化氢与细胞信号通路 本文关键词：硫化氢，通路，药学，细胞，信号
药学翻译-硫化氢与细胞信号通路 本文简介：药学翻译-硫化氢与细胞信号通路泛瑞翻译作者：LiL,RoseP,MoorePK.AnnuRevPharmacolToxicol.2011;51:169-87.PMID:21210746摘要硫化氢（H2S）是胱硫醚γ-裂解酶（CSE）与其他自发酶类分解半胱氨酸所得的一种气体递质。H2S供体药理学试验与
药学翻译-硫化氢与细胞信号通路 本文内容：
药学翻译-硫化氢与细胞信号通路
泛瑞翻译
作者：Li
L,Rose
P,Moore
PK.
Annu
Rev
Pharmacol
Toxicol.
2011;
51:169-87.
PMID:
21210746
摘要
硫化氢（H2S）是胱硫醚γ-裂解酶（CSE）与其他自发酶类分解半胱氨酸所得的一种气体递质。H2S供体药理学试验与CSE基因敲除小鼠遗传实验表明该血管扩张性气体在血管直径、局部缺血/再灌注损伤心脏应变与炎症调节方面有重要作用。几十年前，已确认H2S可抑制细胞色素c氧化酶，并可降低细胞内能量产生。但近年来，发现该气体存在大量其他的药理学靶标。H2S可激活KATP与瞬时受体电位（TRP）通道，常抑制大电导钙激活钾(BKCa)通道、T型钙通道与M型钙通道。H2S可抑制或激活NF-κB核转运，并影响大量激酶的活性，如p38丝裂原活化蛋白激酶（p38
MAPK）、细胞外信号调节激酶（ERK）与Akt等。这些不同效应可能继发于H2S已知的还原性和/或促进细胞内蛋白质半胱氨酸氢硫化的性质。
原文：
Title:
Hydrogen
Sulfide
and
Cell
Signaling
Author:
Li
L,Rose
P,Moore
PK.
Annu
Rev
Pharmacol
Toxicol.
2011;
51:169-87.
PMID:
21210746
Abstract
Hydrogen
sulfide
(H2S)
is
a
gaseous
mediator
synthesized
from
cysteine
by
cystathionine
γ
lyase
(CSE)
and
other
naturally
occurring
enzymes.
Pharmacological
experiments
using
H2S
donors
and
genetic
experiments
using
CSE
knockout
mice
suggest
important
roles
for
this
vasodilator
gas
in
the
regulation
of
blood
vessel
caliber,cardiac
response
to
ischemia/reperfusion
injury,and
inflammation.
That
H2S
inhibits
cytochrome
c
oxidase
and
reduces
cell
energy
production
has
been
known
for
many
decades,but
more
recently,a
number
of
additional
pharmacological
targets
for
this
gas
have
been
identified.
H2S
activates
KATP
and
transient
receptor
potential
(TRP)
channels
but
usually
inhibits
big
conductance
Ca2+-sensitive
K+
(BKCa)
channels,T-type
calcium
channels,and
M-type
calcium
channels.
H2S
may
inhibit
or
activate
NF-κB
nuclear
translocation
while
affecting
the
activity
of
numerous
kinases
including
p38
mitogen-activated
protein
kinase
(p38
MAPK),extracellular
signal-regulated
kinase
(ERK),and
Akt.
These
disparate
effects
may
be
secondary
to
the
well-known
reducing
activity
of
H2S
and/or
its
ability
to
promote
sulfhydration
of
protein
cysteine
moieties
within
the
cell.